長野 正展
Masanobu Nagano

出身地
福岡

好きなもの・こと
スポーツ、好きな音楽探し、買い物ぶらり

研究室に入ってびっくりしたこと？
分析機器がいっぱいある。自由度の高さ。

研究室の雰囲気は？
なんだかみんな優しい。

研究のモチベーションの源は？
挑戦から得られる気付き。前人未到の地がたくさんある。

自分に何か身につけるなら？
ここ１０数年で失われた筋肉たち（特にふくらはぎ）

学歴
2004. 3
第一薬科大学 製剤科 卒業（野上 靖純 教授）
2007. 3
九州大学大学院 薬学研究院 創薬科学専攻 博士前期課程 修了（末宗 洋 教授）
2010. 3
九州大学大学院 薬学研究院 創薬科学専攻 博士後期課程 修了（末宗 洋 教授）

職歴
2007. 4 – 2010. 3
日本学術振興会 特別研究員 DC1
2010. 4 – 2012. 12
The Scripps Research Institute, Research Associate (Prof. Carlos F. Barbas)
2013. 1 – 2020. 8
東京大学大学院 理学系研究科 化学専攻 博士研究員（菅 裕明 教授）
2013. 4 – 2016. 3
日本学術振興会 特別研究員 PD
2020. 9 – Present
東京大学大学院 総合文化研究科 広域科学専攻 特任助教

研究・専門分野
生物有機化学、創薬化学、ケミカルバイオロジー

詳細はこちら（Researchmap）

論文リスト

  1. M. Nagano, K. Kubota, A. Sakata, R, Nakamura, T. Yoshitomi, K. Wakui, K. Yoshimoto*
    “A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice”
    Mol. Ther. Nuc. Acids, 33, 762-772 (2023).
  2. R. Troisi, V. Napolitano, E. Rossitto, M. Nagano, K. Wakui, G. M. Popowicz, K. Yoshimoto, F. Sica*
    “Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide”
    Nucleic Acids Res., 51, 8880-8890 (2023).
  3. M. Nagano, T. Toda, K. Makino, H. Miki, Y. Sugizaki, H. Tomizawa, A. Isobayashi, K. Yoshimoto*
    “Discovery of a highly specific anti-methotrexate (MTX) DNA aptamer for antibody-independent MTX detection”
    Anal. Chem., 94, 17255-17262 (2022).
  4. M. Nagano, S. Nakano, K. Yoshimoto*
    “Evaluation of G-quartet-forming guanines in antiparallel G-quadruplexes by optical spectroscopy and deoxyguanine-to-deoxythymine scanning”
    Anal. Biochem., 658, 114903 (2022).
  5. M. Nagano, Y. Huang, R. Obexer, H. Suga*
    “Chemical Peptide Macrolactonization via Intramolecular S-to-S-to-O Acyl Transfer”
    Pep. Sci., 114, e24259 (2022). Selected as a cover image of the issue.
  6. M. Nagano, S. Satoshi, H. Suga*
    “Inner Residues of Macrothiolactone in Autoinducer Peptides I/IV Circumvents Spontaneous S-to-O Acyl Transfer to the Upstream Serine Residue”
    RSC Chem. Biol., 3, 295-300 (2022).
  7. M. Nagano, T. Oguro, R. Sawada,T. Yoshitomi, K. Yoshimoto*
    “Accelerated Discovery of Potent Bioactive anti-TNFα Aptamers by Microbead-Assisted (MACE)-SELEX”
    ChemBioChem,  22, 3341-3347 (2021).
  8. A. Vinogradov,* M. Nagano, Y. Goto, H. Suga*
    “Site-Specific Nonenzymatic Peptide S/O-Glutamylation Reveals the Extent of Substrate Promiscuity in Glutamate Elimination Domains”
    J. Am. Chem. Soc., 143, 13358-13369 (2021).
  9. M. Nagano, Y. Huang, R. Obexer, H. Suga*
    “One-Pot In Vitro Ribosomal Synthesis of Macrocyclic Depsipeptide”
    J. Am. Chem. Soc., 143, 4741-4750 (2021).
  10. N. K. Bashiruddin, M. Hayashi, M. Nagano, Y. Yu, J. Takagi, H. Suga*
    “Development of Cyclic Peptides with Potent In Vivo Osteogenic Activity through RaPID-based Affinity Maturation”
    Proc. Natl. Acad. Sci. USA, 117, 31070-31077 (2020)
  11. H. Peacock, S. T. Henriques, A. H. Benfield, A. G. Elliott, J. Luo, J. Luccarelli, M. Nagano, D. J. Craik, A. D. Hamilton*
    “Antimicrobial Peptide Mimetics Based on a Biphenylacetylene Scaffold: Synthesis, Conformational Analysis and Activity”
    ChemMedChem, 15, 1932-1939 (2020)
  12. Koike, M. Nagano, M. Ebihara, T. Hirayama, M. Tsuji, H. Suga, H. Nagasawa*
    “Design, Synthesis and Conformation-Activity Study of Unnatural Bridged Bicyclic Depsipeptides as Highly Potent HIF-1 Inhibitors and Antitumor Agents”
    J. Med. Chem., 63, 4022-4046 (2020)
  13. N. K. Bashiruddin, Y. Matsunaga, M. Nagano, J. Takagi, H. Suga*
    “Facile Synthesis of Dimeric Thioester-Macrocyclic Peptides with Antibody-like Affinity against Plexin-B1”
    Bioconjugate Chem., 29, 1847-1851 (2018)
  14. M. Nagano*, N. Carrillo, N. Otsubo, H. Ban, W. Hakamata, R. F. Fuller, N. K. Bashiruddin, C. F. Barbas, III
    “In Vivo Programming of Endogenous Antibodies via Oral Administration of Adaptor Ligands”
    Bioorg. Med. Chem., 25, 5952-5961 (2017)
  15. Katoh, I. Wohlgemuth, M. Nagano, M. V. Rodina, H. Suga*
    “Essential Structural Elements in Prolyl-tRNAPro for EF-P-Mediated Alleviation of Translation Stalling”
    Nat. Commun., 7, 11657–11669 (2016)
  16. N. K. Bashiruddin, M. Nagano, H. Suga*
    “Synthesis of Fused Tricyclic Peptides using a Reprogrammed Translation System and Chemical Modification”
    Bioorg. Chem., 61, 45-50 (2015)
  17. T. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Nagano, H. Suemune, M. Tanaka*
    “Amino Equatorial Effect of a Six-Membered Ring Amino Acid on Its Peptide 310– and α-Helices”
    Tetrahedron, 71, 2409-2420 (2015)
  18. M. Oba, H. Takazaki, N. Kawabe, M. Doi, Y. Demizu, M. Kurihara, H. Kawakubo, M. Nagano, H. Suemune, M. Tanaka*
    “Helical Peptide-Foldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups”
    J. Org. Chem., 79, 9125-9140 (2014)
  19. H. Ban‡, M. Nagano‡, J. Gavrilyuk, W. Hakamata, C. F. Barbas, III*  (‡  Contributed equally)
    “Facile and Stabile Linkages Through Tyrosine: Bioconjugation Strategies with the Tyrosine-Click Reaction”
    Bioconjugate Chem., 24, 520-532 (2013)
  20. J. Gavrilyuk, H. Ban, M. Nagano, W. Hakamata, C. F. Barbas, III*
    “Formylbenzene Diazonium Hexafluorophosphate Reagent for Tyrosine-selective Modification of Proteins and the Introduction of a Bioorthogonal Aldehyde”
    Bioconjugate Chem., 23, 2321-2328 (2012)
  21. Y. Demizu, M. Doi, M. Kurihara, H. Okuda, M. Nagano, H. Suemune, M. Tanaka*
    “Conformational Studies on Peptides Containing α,α-Disubstituted α-Amino Acids: Chiral Cyclic α,α-Disubstituted α-Amino Acid as an α-Helical inducer”
    Org. Biomol. Chem., 9, 3303–3312 (2011)
  22. M. Nagano, M. Doi, M. Kurihara, H. Suemune, M. Tanaka*
    “Stabilized α-Helix-Catalyzed Enantioselective Epoxidation of α,β-Unsaturated Ketones”
    Org. Lett., 12, 3564–3566, (2010)
  23. M. Nagano, M. Tanaka, M. Doi, Y. Demizu, M. Kurihara, H. Suemune*
    “Helical-Screw Directions of Diastereomeric Cyclic α-Amino Acid Oligomers”
    Org. Lett., 11, 1135–1137, (2009)
  24. Y. Demizu, M. Tanaka, M. Nagano, M. Kurihara, M. Doi, T. Maruyama, H. Suemune*
    “Controlling 310-Helix and α-Helix of Short Peptides in the Solid State”
    Chem. Pharm. Bull., 55, 840–842, (2007)
  25. M. Tanaka, Y. Demizu, M. Nagano, M. Hama, Y. Yoshida, M. Kurihara, M. Doi, H. Suemune*
    “Lipase-Catalyzed Kinetic Resolution of Cyclic trans-1,2-Diols Bearing a Diester Moiety: Synthetic Application to Chiral Seven-Membered-Ring α,α-Disubstituted α-Amino Acid”
    J. Org. Chem., 72, 7750–7756 (2007)

2022年 11月21日　更新