吉冨 徹
Toru Yoshitomi

2019年4月10日　更新

学歴
2005.03
東京理科大学　基礎工学部　材料工学科　卒業
2007.03
筑波大学大学院　数理物質科学研究科　物性・分子工学専攻
博士前期課程　修了
2009.10
米国国立衛生研究所（NIH）短期留学
2009.11
オハイオ州立大学　短期留学
2010.03
筑波大学大学院　数理物質科学研究科　物性・分子工学専攻
博士後期課程　修了
2010.03
博士（工学）　取得

職歴
2010.04-2013.03
筑波大学大学院　数理物質科学研究科　博士研究員
2013.04-2015.10
日本学術振興会　特別研究員　（東京大学　理学系研究科　所属）
2015.10-現在
東京大学大学院総合文化研究科広域科学専攻・助教

Publons

発表論文（投稿中を含む）

  1. Toru Yoshitomi, Keiko Kimura, Misako Hayashi, Fumiya Wayama, Hitoshi Furusho, Keitaro Yoshimoto, submitted.
  2. Toru Yoshitomi, Saeko Kaminaga, Naoki Sato, Toyoshima M., Moriyama T., Keitaro Yoshimoto, Formation of Spherical Palmelloid Colony with Enhanced Lipid Accumulation by Gel Encapsulation of Chlamydomonas debaryana NIES-2212, Plant & Cell Physiology, accepted.
  3. Toru Yoshitomi, Naoya Shimada, Kazutoshi Iijima, Mineo Hashizume, Keitaro Yoshimoto, Polyethyleneimine-induced astaxanthin accumulation in the green alga Haematococcus pluvialis by increased oxidative stress, Journal of Bioscience and Bioengineering, in press.
  4. Koji Wakui, Akihito Abe, Toru Yoshitomi, Hitoshi Furusho, Keitaro Yoshimoto.  High Enrichment of Nucleobase-Modified Aptamers in Early Selection Rounds by Microbeads-Assisted Capillary Electrophoresis SELEX.　Analytical Sciences, 35(5), 585 (2019).
  5. Koji Wakui, Toru Yoshitomi, Akane Yamaguchi, Maho Tsuchida, Shingo Saito, Masami Shibukawa, Hitoshi Furusho, Keitaro Yoshimoto.  Rapidly Neutralizable and High Anticoagulant Thrombin-Binding DNA Aptamer Discovered by Microbeads-Assisted Capillary Electrophoresis (MACE) SELEX.  Molecular Therapy Nucleic Acids, 16, 348-359 (2019).
    doi:10.1016/j.omtn.2019.03.002
  6. Toru Yoshitomi, Fumiya Wayama,  Keiko Kimura, Koji Wakui,  Hitoshi Furusho,  Keitaro Yoshimoto.  Screening of DNA signaling aptamer from multiple candidates obtained from SELEX with next-generation sequencing. Analytical Sciences, 35(1):113(2019). doi:10.2116/analsci.18SDN05
  7. Junya Yoshioka, Yu Ohsugi, Toru Yoshitomi, Tomoyuki Yasukawa, Naoki Sasaki, Keitaro Yoshimoto, Label-free rapid separation and enrichment of bone marrow-derived mesenchymal stem cells from heterogeneous cell mixture using a dielectrophoresis device. Sensors. 18(9):3007(2018). doi:10.3390/s18093007
  8. Zheng, Hangyu., Toru Yoshitomi,  Keitaro Yoshimoto,  Analysis of Chirality Effects on Stem Cell Fate Using Three-dimensional Fibrous Peptide Hydrogels. ACS Applied Bio Materials, 1(3):538-543(2018). doi:10.1021/acsabm.8b00123
  9. Ryo Maruyama, Kurumi Makino, Toru Yoshitomi, Hiroharu Yui, Hitoshi Furusho,  Keitaro Yoshimoto. Estimation of G-Quartet-Forming Guanines in Parallel-Type G-Quadruplexes by Optical Spectroscopy Measurements of Their Single-Nucleobase Substitution Sequences. Analyst, 143, 4022-4026 (2018). doi:10.1039/C8AN01131A
  10. Shunsuke Tomita, Hiroki Nomoto, Toru Yoshitomi, Kazutoshi Iijima, Mineo Hashizume, and Keitaro Yoshimoto. Noninvasive Fingerprinting-Based Tracking of Replicative Cellular Senescence Using a Colorimetric Polyion Complex Array. Anal Chem., 90(11):6348-6352 (2018). doi: 10.1021/acs.analchem.8b00795.
  11. Yasuhiko Iwasaki,  Atsushi Yokota,  Akihisa Otaka,  Naoyuki Inoue,  Akane Yamaguchi,  Toru Yoshitomi,  Keitaro Yoshimoto  and  Masashi Neo. Bone-targeting poly(ethylene sodium phosphate). Biomater Sci., 6(1):91-95 (2018). doi:10.1039/c7bm00930e.
  12. Hiroshi Asanuma, Shoji Sanada, Toru Yoshitomi, Hideyuki Sasaki, Hiroyuki Takahama, Madoka Ihara, Yoshiro Shinozak, Hidezo Mori, Masanori Asakura, Atsushi Nakano, Masaru Sugimach, Yoshihiro Asan3, Tetsuo Minamino, Seiji Takashima, Yukio Nagasaki, Masafumi Kitakaze, Novel Synthesized Radical-Containing Nanoparticles Limits Infarct Size Following Ischemia and Reperfusion in Canine Hearts – Role of Nitric Oxide, Cardiovascular Drugs and Therapy, 31(5-6):501-510 (2017). doi: 10.1007/s10557-017-6758-6.
  13. Kanako Shiota, Susumu Hama, Toru Yoshitomi, Yukio Nagasaki, Kentaro Kogure, Prevention of UV-Induced Melanin Production by Accumulation of Redox Nanoparticles in the Epidermal Layer via Iontophoresis, Biol Pharm Bull., 40(6):941-944 (2017). doi: 10.1248/bpb.b17-00155.
  14. Yuichi Furuhata, Toru Yoshitomi, Yuka Kikuchi, Miho Sakao, and Keitaro Yoshimoto, Osteogenic Lineage Commitment of Adipose-Derived Stem Cells Is Predetermined by Three-Dimensional Cell Accumulation on Micropatterned Surface. ACS Appl Mater Interfaces., 9(11):9339-9347 (2017). doi: 10.1021/acsami.6b15688.
  15. Junya Yoshioka, Toru Yoshitomi, Tomoyuki Yasukawa, Keitaro Yoshimoto,　Alternation of Gene Expression Levels in Mesenchymal Stem Cells by Applying Positive Dielectrophoresis, Analytical Science, 32(11):1213-1216 (2016) doi: 2116/analsci.32.1213
  16. Sindhu Thangavel, Toru Yoshitomi, Meena Kishore Sakharkar, Yukio Nagasaki*, Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects, Biomaterials, 99, 109-123 (2016). (doi:10.1016/j.biomaterials.2016.05.001)
  17. Sindhu Thangavel, Toru Yoshitomi, Meena Kishore Sakharkar and Yukio Nagasaki*, Redox nanoparticles inhibit curcumin oxidative degradation and enhance its therapeuc effect on prostate cancer, Journal of Controlled Release, 209, 110-119 (2015). (doi: 10.1016/j.jconrel.2015.04.025)
  18. Akiko Eguchi, Toru Yoshitomi, Milos Lazic, Casey D. Johnson, Long Binh Vong, Alexander Wree, Davide Povero, Bettina G. Papouchado, Yukio Nagasaki and Ariel E. Feldstein*, Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis, Nanomedicine, 1-12 (2015). (doi: 10.2217/nnm.15.87)
  19. Pennapa Chonpathompikunlert, Toru Yoshitomi, Long Binh Vong, Natsuka Imaizumi, Yuki Ozaki and Yukio Nagasaki*, Recovery of Cognitive Dysfunction via Orally Administered Redox-polymer Nanotherapeutics in SAMP8 mice, PLoS ONE, 10(5): e0126013 (2015). (doi: 10.1371/journal.pone.0126013)
  20. Long Binh Vong, Toru Yoshitomi, Hirofumi Matsui and Yukio Nagasaki*, Development of an oral nanotherapeutics using redox nanoparticles for treatment of colitis-associated colon cancer, Biomaterials, 55, 54-63 (2015). (doi:10.1016/j.biomaterials.2015.03.037)
  21. Madoka Shimizu, Toru Yoshitomi and Yukio Nagasaki*, The Behavior of ROS-Scavenging Nanoparticles in Blood, Journal of Clinical Biochemistry and Nutrition, 54(3), 166-173(2014). (doi: 10.3164/jcbn.13-85)
  22. Toru Yoshitomi, Sha Sha, Long Binh Vong, Pennapa Chonpathompikunlert, Hirofumi Matsui, and Yukio Nagasaki*, Indomethacin-loaded redox nanoparticles improve oral bioavailability of indomethacin and suppress its small intestinal inflammation, Therapeutic Delivery, 5(1), 29-38 (2014). (doi: 10.4155/tde.13.133)
  23. Yukio Nagasaki*, Tatsuya Yaguchi, Takuma Matsumura, Toru Yoshitomi, Yutaka Ikeda, Atsushi Ueda and Aki Hirayama, Design and use of silica-containing redox nanoparticles, siRNP for high-performance peritoneal dialysis, Biomaterials Science, 2(4), 522-5298(2014). (doi: 1039/C3BM60236B)
  24. Chiaki Abe, Yoshihiro Uto*, Ayaka Kawasaki, Chiho Noguchi, Ryo Tanaka, Toru Yoshitomi, Yukio Nagasaki, Yoshio Endo and Hitoshi Hori, Evaluation of the in vivo antioxidative activity of redox nanoparticles by using a developing chicken egg as an alternative animal model, Journal of Controlled Release, 182, 67-72(2014). (doi: 10.1016/j.jconrel.2014.03.015)
  25. Long Binh Vong, Toru Yoshitomi, Kazuya Morikawa, Shinji Saito, Hirofumi Matsui and Yukio Nagasaki*, Oral nanotherapeutics: Effect of redox nanoparticle on microflora in mice with dextran sodium sulfate-induced colitis, Journal of Gastroenterology, 49(5), 806-813 (2014). (doi: 10.1007/s00535-013-0836-8)
  26. Toru Yoshitomi, Kazuhiro Kuramochi, Long Binh Vong and Yukio Nagasaki*, Development of nitroxide radicals-containing polymer for scavenging ROS from cigarette smoke, Science and Technology for Advanced Materials, 15, 035002(2014). (doi: 10.1088/1468-6996/15/3/035002)
  27. Sha Sha, Long Binh Vong, Pennapa Chonpathompikunlert, Toru Yoshitomi, Hirofumi Matsui and Yukio Nagasaki*, Suppression of NSAID-induced Small Intestinal Inflammation by Orally Administered Redox Nanoparticles, Biomaterials, 34, 8393-8400(2013). (doi: 10.1016/j.biomaterials.2013.06.032)
  28. Toru Yoshitomi, Yuki Ozaki, Sindhu Thangavel and Yukio Nagasaki*, Redox Nanoparticle Therapeutics to Cancer -Increase in therapeutic effect of doxorubicin, suppressing its adverse effect-, Journal of Controlled Release, 172(1), 137-143 (2013). (doi:10.1016/j.jconrel.2013.08.011)
  29. Min Ley Pua, Toru Yoshitomi, Pennapa, Chonpathompikunlert, Aki Hirayama and Yukio Nagasaki*, Redox-active Injectable Gel Using Thermo-responsive Nanoscale Polyion Complex Flower Micelle for Noninvasive Treatment of Local Inflammation, Journal of Controlled Release, 172(3), 914-920 (2013). (doi: 10.1016/j.jconrel.2013.10.009)
  30. Toru Yoshitomi, Yu Yamaguchi, Akihiko Kikuchi and Yukio Nagasaki*, Creation of a blood-compatible surface: a novel strategy for suppressing blood activation and coagulation using nitroxide radical-containing polymer with reactive oxygen species scavenging activity, Acta Biomaterialia, 8, 1323-1329 (2012). (doi: 10.1016/j.actbio.2011.11.029)
  31. Toru Yoshitomi and Yukio Nagasaki*, Design and preparation of a nanoprobe for imaging inflammation sites, Biointerphase, 7:7 (2012). (DOI 10.1007/s13758-011-0007-5)
  32. Pennapa Chonpathompikunlert, Ching-Hsiang Fan, Yuki Ozaki, Toru Yoshitomi, Chih-Kuang Yeh and Yukio Nagasaki*, Redox Nanoparticle Treatment Protects Against Neurological Deficit in Focused Ultrasound-Induced Intracerebral Hemorrhage, Nanomedicine, 7(7), 1029-1043 (2012). (doi: 10.2217/nnm.12.2)
  33. Long Binh Vong, Tsutomu Tomita, Toru Yoshitomi, Hirofumi Matsui and Yukio Nagasaki*, An Orally Administered Redox Nanoparticle that Accumlates in the Colonic Mucosa and Reduces Colitis in Mice, Gastroenterology, 143(4), 1027-1036(2012). (doi: 10.1053/j.gastro.2012.06.043)
  34. Yutaka Ikeda, Rie Suzuki, Toru Yoshitomi and Yukio Nagasaki*, Novel oligonucleotide carrier possessing reactive oxygen species scavenging ability, Macromolecular Bioscience, 11, 344-351 (2011). (DOI: 10.1002/mabi.201000305)
  35. Aiki Marushima, Hideo Tsurusima, Toru Yoshitomi, Kazuko Toh, Aki Hirayama, Yukio Nagasaki and Akira Matumura*, Newly Synthesized Radical-containing Nanoparticles (RNP) Enhance Neuroprotection after Cerebral Ischemia-reperfusion Injury, Neurosurgery, 68, 1418-1426 (2011). (doi: 10.1227/NEU.0b013e31820c02d9)
  36. Chonpathompikunlert  Pennapa , Toru Yoshitomi, Han Junkyu, Kazuko Toh, Hiroko Isoda and Yukio Nagasaki*, Chemical Nanotherapy-Nitroxyl Radical-containing Nanoparticle (RNP) Protects Neuroblastoma SH-SY5Y cells from Aß-induced Oxidative Stress, Therapeutic Delivery, 2(5), 585–597 (2011). DOI 10.4155/tde.11.27
  37. Toru Yoshitomi, Aki Hirayama and Yukio Nagasaki*, The ROS scavenging and renal protective effects of pH-responsive nitroxide radical-containing nanoparticles, Biomaterials, 32, 8021-8028 (2011). (doi: 10.1016/j.biomaterials.2011.07.014)
  38. Chonpathompikunlert Pennapa, Toru Yoshitomi, Han Junkyu, Hiroko Isoda and Yukio Nagasaki*, The Use of Nitroxide Radical-containing Nanoparticles Coupled with Piperine to Protect Neuroblastoma SH-SY5Y cells from Aβ-Induced Oxidative Stress, Biomaterials, 32, 8605-8612 (2011). (doi: 10.1016/j.biomaterials.2011.07.024)
  39. Kazuko Toh, Toru Yoshitomi, Yutaka Ikeda, Yukio Nagasaki*, Novel redox nanomedicine improves gene expression of polyion complex vector, Science and Technology of Advanced Materials, 12,　065001 (2011). (doi:10.1088/1468-6996/12/6/065001)
  40. 丸島 愛樹, 鈴木 謙介, 長崎 幸夫, 吉冨 徹, 藤 加珠子, 鶴嶋 英夫, 平山 暁, 松村 明*、脳虚血再灌流における酸化ストレス障害と脳保護療法─pH応答性ラジカル含有ナノ粒子(radical-containing nanoparticle: RNP)の可能性─、脳卒中、552-558, 32 (2010). (org/10.3995/jstroke.32.552)
  41. Toru Yoshitomi, Daisuke Miyamoto and Yukio Nagasaki*, Design of Core-shell-type Nanoparticles Carrying Stable Radicals in the Core, Biomacromolecules,10(3) 596-601(2009). (doi: 1021/bm801278n)
  42. Toru Yoshitomi, Rie Suzuki, Takashi Mamiya, Matsui Hirofumi, Aki Hirayama and Yukio Nagasaki*, pH-Sensitive Radical-Containing-Nanoparticle (RNP) for the L-Band-EPR Imaging of Low pH Circumstances., Bioconjugate Chemistry, 20 1792-1798 (2009). (doi: 10.1021/bc900214f)
  43. Toru Yoshitomi, Daisuke Miyamoto and Yukio Nagasaki*, Design of Polymeric Micelle with Stable Radicals in the Core from Acetal-poly(ethylene glycol)-b-poly(chloromethylstyrene), Transactions of the Materials Research Society of Japan, 33(3), 783-786(2008).

総説

  1. Toru Yoshitomi and Yukio Nagasaki*, Development of Silica-containing Redox Nanoparticles for Medical Applications, Biomaterials Science, 3, 810-815 (2015). (doi: 10.1039/C5BM00057B).
  2. Toru Yoshitomi and Yukio Nagasaki*, ROS-scavenging Nanomedicine for Treatment of Oxidative Stress Injuries, Advanced Healthcare Materials, 3(8), 1149-1161(2014). (doi: 10.1002/adhm.201300576)
  3. 長野正展、吉冨徹、菅裕明*、未来を切り拓く特殊ペプチド創薬,ファルマシア, 50(8), 751-755(2014)
  4. 菅裕明*、吉冨徹、長野正展、機能性大環状ポリペプチドの翻訳合成とRaPID探索、高分子、63, 712-714 (2014)
  5. 吉冨徹*、活性酸素を消去するナノメディシンによる酸化ストレス疾患の治療、Drug Delivery System, 29(1), 88-89（2014）
  6. Toru Yoshitomi and Yukio Nagasaki*, Nitroxyl radical-containing nanoparticles for novel nanomedicine against oxidative stress injury, Nanomedicine, 6(3), 509-518 (2011).(doi: 10.2217/nnm.11.13)

著書

  1. Toru Yoshitomi, Long Binh Vong, Yukio Nagasaki: Chapter 22, Nanomedice for the Treatment of Oxidative Stress Injuries, Genomics and Drug Discovery, River Publishers, 589-607, 2014
  2. 吉冨徹、長崎幸夫：第10章、ニトロキシルラジカル含有コア－シェル型ナノ粒子の作製と機能、コアシェル微粒子の設計・合成技術・応用の展開、シーエムシー出版、平成22年7月出版

受賞歴

  1. ポスター賞
    Toru Yoshitomi, Daisuke Miyamoto, Yukio Nagasaki
    Synthesis of acetal-poly(ethylene glycol)-b-poly(chloromethylstyrene) and application
    for functional bioimaging nanosphere, 18th Symposium of Materials Research
    Society of Japan, 2007年12月8日
  2. 最優秀賞
    吉冨　徹, 間宮　孝,　松井　裕史,　平山　暁,　長崎　幸夫: 生体内ESRイメージング
    を目指したTEMPO内包コアシェル型ナノ粒子の設計、Symposium 2008 of the
    Japanese society for biomaterials, 東京, 2008年11月17~18日
  3. Young Investigator Award 2009
    JSPS core-to-core Program”Center for Magnetic Resonance Molecular Imaging of In
    Vivo Redox System”, 2009年6月
  4. 最優秀賞
    吉冨　徹、間宮　孝、松井　裕史、 平山　暁、長崎　幸夫：生体内酸性環境の可視
    化を目指した安定ラジカル含有pH応答型キャリアの設計と評価、第38回　医用高
    分子シンポジウム、東京大学先端科学技術研究センター, 東京, 2009年07月27日
  5. Young Investigator Award
    Toru Yoshitomi, Takashi Mamiya, Hirofumi Matsui, Aki Hirayama, Yukio
    Nagasaki: Design of pH-sensitive polymeric micelle possessing reduced forms
    of TEMPO for imaging of ROS
    The 2010 World Congress of the Oxygen Club of California, Fess Parker’s
    DoubleTree Resort, Santa Barbara, California , 2010年03月17-20日.
  6. 第25回日本酸化ストレス学会関東支部会 関東支部会長賞
    吉冨 徹、平山 暁、長崎 幸夫: 腎臓虚血－再灌流障害に対する新規ナノ治療の開
    発,日本酸化ストレス学会関東支部会,タワーホール船堀, 東京, 2010年12月11日
  7. 日本酸化ストレス学会 奨励賞
    吉冨　徹、平山　暁、長崎　幸夫：レドックス反応性ナノ粒子による腎虚血再灌流障
    害の治療、第64回日本酸化ストレス学会、留寿都、北海道、2011年7月2日-3日.
  8. Award for Encouragement of Research in Thin Films
    Toru Yoshitomi, Yu Yamaguchi, Akihiko Kikuchi, Yukio Nagasaki: Improved Blood
    Compatibility of Nitroxide Radicals Containing Surface – Nitroxide Radicals in
    Polymer Effectively React with ROS,15th International Conference on Thin Films
    (ICTF-15), 京都, 2011年8月3日
  9. Informa Healthcare Young Investigator Award 2011
    Toru Yoshitomi, Long Binh Vong, Hirofumi Matsui, Yukio Nagasaki: Ulcerative
    colitis treatment by nitroxide radical-containing nanoparticle, The 5th Biennial
    Meeting of Society for Free Radical Research-Asia (SFRR-Asia), Kagoshima,
    Japan, 2011年8月31日-9月4日.
  10. 優秀発表者賞
    吉冨 徹、平山 暁、長崎 幸夫: 虚血部位崩壊型レドックス反応性ナノ粒子による腎
    虚血再灌流障害の治療、第28回日本DDS学会学術集会、札幌コンベンション、2012年7月5日
  11. 日本バイオマテリアル学会「2012JSB/KSB若手研究者交流AWARD
    Toru Yoshitomi, Aki Hirayama and Yukio Nagasaki: Nanotherapy of Renal Ischemiareperfusion Injury by pH-responsive Redox Nanoparticle, 20th MEETING OF THE
    KOREA SOCIETY FOR BIOMATERIALS, Seoul, Korea, 2012年11月15日
  12. 第11回　わかしゃち奨励賞
    酸化還元反応性高分子ゲルによる微細藻類バイオ燃料生産法の開発、2017年1月30日
  13. 第13回ナノ・バイオメディカル学会
    Chirality effects on stem cell behavior in threedimensional nanofibrous peptide/polymer hybrid hydrogels、東京理科大学、2018年11月27日
  14. 公益財団法人　八洲環境技術振興財団　平成28年度　研究開発・調査助成　八洲奨励賞
    機能性アルギン酸ハイドロゲルによる微細藻類細胞の大規模培養法の開発、第一ホテル東京、2019年3月7日

招待講演実績

  1. 2010.02.18 Yukio Nagasaki, Toru Yoshitomi: Novel Nanosphere Theranostic for
    Anti-Oxidative Stress, THE 1st INTERNATIONAL CONFERENCE FOR GREEN
    TECHNOLOGIES, Ajou University, Suwon, Korea.
  2. 2012.4.27 Toru Yoshitomi, Aki Hirayama, Yukio Nagasaki, Nanotherapy of kidney
    Ischemia-reperfusion Injury by pH-sensitive Redox Nanoparticle, International
    Advanced Drug Delivery System (IADDS), Industrial Technology Research
    Institute, Hsinchum, Taiwan
  3. 2015.10.30 吉冨　徹、活性酸素を消去するバイオマテリアルの開発と機能性ポリペプチド探索法の開発、高分子学会 バイオマテリアル若手研究会、八王子セミナーハウス

研究・専門分野
高分子化学、生体医工学、藻類細胞工学

所属学会
高分子学会、バイオマテリアル学会、日本DDS学会、日本酸化ストレス学会、日本生物工学会、日本植物学会

担当講義等
基礎化学実験（学部1・2年生）、全学ゼミ（学部1・2年生）、「統合生命科学への招待」オムニバス講義